|
|
UCSD Clinical Investigation Institute-Nature Medicine
Frontiers of Clinical Investigation Symposium
Autoimmunity 2005: Bench to Bedside (B2B)
September 15-17, 2005
PROGRAM
|
| Thursday, September 15, 2005 |
| 4:00 - 6:00PM |
REGISTRATION |
| 6:00 - 8:00PM |
Wine and Cheese Welcome Reception and Poster Session
|
| Friday, September 16, 2005 |
| 7:30 - 8:00AM |
Continental Breakfast |
| 8:00 - 8:15AM |
Opening Remarks
Gary S. Firestein, MD (UCSD),
Juan Carlos Lopez, PhD (Nature Medicine) |
| 8:15 - 10:15AM |
OF MICE AND MEN: USING ANIMAL MODELS
TO PREDICT EFFICACY
Chair: Dennis Carson, MD (UCSD)
Vijay K. Kuchroo, PhD (Harvard)
"Role of Rodent Models in the Evaluation of Multiple Sclerosis"
Gary S. Firestein, MD (UCSD)
"Rheumatoid Arthritis in Mice: Evaluating Novel Therapeutic Targets"
Abstract Presentations (two presentations - 10 minutes each)
SCIENTIFIC KEYNOTE: 2004 Lasker Prize Winner
Ronald M. Evans, PhD (SALK)
"PPARs: From Molecule to Man"
|
| 10:15 - 10:30AM | Break |
| 10:30AM - 12:30PM |
BIOMARKER ENDPOINTS IN CLINICAL TRIALS
Chair: Anthony M. Manning, PhD (ROCHE)
William C. Eckelman, PhD (NIH)
"Imaging Studies in Pre-clinical Drug Development"
J. Lee Nelson, MD (UNIV. WASHINGTON)
"Gene Expression Signatures: A Unique Biomarker in Systemic Lupus Erythematosis"
James G. Krueger, MD, PhD (ROCKEFELLER)
"The Genomic Approach to Dissecting Pathogenesis of an Autoimmune Skin Disease (Psoriasis)"
Lawrence Steinman, MD (STANFORD)
"Genomic and Proteomic Scans: Lesson from Multiple Sclerosis"
|
| 12:30 - 1:30PM | Hosted Lunch |
| 1:30 - 3:15PM |
WORKING WITH REGULATORY AGENCIES
Chair: Arthur F. Kavanaugh, MD (UCSD)
Lee S. Simon, MD (HARVARD)
"Developing Criteria and Endpoints for Autoimmune Diseases"
Salvatore Albani, MD, PhD (UCSD)
"Bench to Bedside: The Academic Perspective"
Bernhardt G. Zeiher, MD (PFIZER)
"Bench to Bedside: The Industry Perspective"
Sharon Hertz, MD (FDA)
"Efficacy vs. Safety: The FDA Position"
|
| 3:15 - 3:30PM |
Break |
| 3:30 - 5:30PM |
NOVEL IMAGING MODALITIES IN CLINICAL INVESTIGATION
Chair: Robert F. Mattrey, MD (UCSD)
Michael L. Dustin, PhD (NYU)
"In Vivo Imaging of Inflammation"
Donald McDonald, MD, PhD (UCSF)
"Non-invasive In Vivo Biomarker Imaging"
Robert F. Mattrey, MD (UCSD)
"Molecular Imaging: In Vivo Enzyme Assays"
Robert I. Grossman, MD (NYU)
"Novel Imaging of Plaques and CNS Function in Multiple Sclerosis"
|
| 6:00 - 9:30PM |
Reception and Dinner - Scripps Aquarium
|
| Saturday, September 17, 2005 |
| 7:30 - 8:15AM |
Continental Breakfast |
| 8:15 - 10:30AM |
CLINICAL TRIAL DESIGN: SHIFTING THE PARADIGM
Chair: Ravindra L. Mehta, MBBS, MD (UCSD)
Michael E. Phelps, PhD (UCLA)
"Validating Biomarkers: When Does it Become a Surrogate Marker?"
Robert J. Temple, MD (FDA)
"Placebo Controls vs. Active Comparators for Immunomodulators?"
Leslie A. Lenert, MD (UCSD)
"Web-based Instruments to Acquire and Process Patient Information"
Abstract Presentations (two presentations - 10 minutes each)
|
| 10:30 - 10:45AM |
Break |
| 10:45AM - 12:45PM |
LOOKING TO THE FUTURE: CLINICAL RESEARCH 2010
Chair: Ravindra L. Mehta, MBBS, MD (UCSD)
Nancy Olson, MD (UT SOUTHWESTERN)
"Stratifying Patients in Clinical Trials Based on Genomic and Proteomic Data"
Alessandro Sette, PhD (LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY)
"Immuno-Informatics in Translational Medicine"
Gerald T. Nepom, MD, PhD (VIRGINIA MASON)
"Reinterpreting Autoimmune Disease Susceptibility through the Clinical Trial Experience"
|
| 12:45PM |
Closing Remarks
Ravindra Mehta, MBBS, MD,
Juan Carlos Lopez, PhD
|
| 12:50PM |
Final Adjournment |
|
|
