The theme for this year’s symposium explores innovative approaches to bridge laboratory investigation to clinical research in aging. The topic stands at the cross roads of many disciplines, including endocrinology, cardiology, neurodegenerative, and musculoskeletal diseases. Multi-disciplinary sessions will include basic, translational, and clinical presentations on cutting edge research to provide an integrated approach to understanding the science of healthy aging. Last year, the theme was Host Defense, and future year themes will include topics such as metabolism, cancer, and inflammation. This symposium will provide unique insights and tools for optimizing and streamlining clinical investigation from discovery to drug development.