Frontiers of Clinical Investigation Symposium

Thursday, October 13, 2011
3:00 – 4:00 PM	Registration
4:00 – 4:15	Overview Gary Firestein
4:15 – 5:00	SCIENTIFIC KEYNOTE Napoleone Ferrara, MD, PhD
5:00 – 6:30 PM	Poster Session and Wine & Cheese Reception
Friday, October 14, 2011
7:30 – 8:10 AM	Registration and Continental Breakfast
8:10 – 8:15	Overview
8:15 – 10:15	ANGIOGENIC TRIGGERS AND REGULATION Moderator: David Cheresh “Omics” Approaches to Identifying Novel Targets in Angiogenesis Renata Pasqualini and Wadih Arap Regulation of Angiogenesis by Innate Immunity and Oxidative Damage Tatiana Byzova In Vivo Evaluation of Angiogenesis Rakesh Jain Q & A
10:15 – 10:30	Break
10:30 – 12:30 PM	VASCULAR INFLAMMATION AND REMODELING Moderator: Wolfram Ruf Neutrophil Extracellular Traps Paul Kubes Vaso-Occlusive Crisis in Sickle Cell Disease Paul Frenette Epigenetics and Vasculitis Ronald J. Falk Q & A
12:30 – 1:30	Lunch
1:30 – 3:30	VASCULAR MALFORMATION Moderator: Michael Basson Mechanism of Cerebral Cavernous Malformation Dean Li Self Renewal and Blood Vessel Assembly of Infantile Hemangioma-derived Stem Cells Joyce Bischoff Rho-Kinase Inhibition in Cerebral Cavernous Malformations Lesion Genesis Rebecca Stockton A Mek-Independent Role for Craf in Mitosis, Angiogenesis and Tumor Progression Ainhoa Mielgo Q & A
3:30 – 3:45	Break
3:45 – 5:35	VASCULAR HOMEOSTASIS AND INJURY Moderator: Klaus Ley VEGF and Renal Injury Susan Quaggin The Role of Adenosine Signaling in Ischemia-Reperfusion Injury Holger Eltzschig Angiogenesis and the Blood Brain Barrier Ryan Watts Q & A
5:35 PM	Adjourn for the Day
Saturday, October 15, 2011
7:30 – 8:10 AM	Registration and Continental Breakfast
8:10 – 8:15	Introduction
8:15 – 10:05	PERSPECTIVES ON CLINICAL CARDIOVASCULAR STUDIES Moderator: Sam Tsimikas Metabolite Profiling to Inform Clinical Trials Robert Gerszten Imaging Cardiovascular Disease in Clinical Research Jagat Narula Vanin-1 Pantetheinase Drives Smooth Muscle Cell Activation in Vascular Remodeling Jagadeesha Dammanahalli Spleen Tyrosine Kinase Regulates Transcriptional Activation Of Ap-1 Responses to Minimally Oxidized Ldl in Macrophages Soo-Ho Choi Q & A
10:05 – 10:20	Break
10:20 – 12:20 PM	MECHANISMS OF ATHEROSCLEROSIS AND HEART DISEASE Moderator: Yuri Miller Identifying Risk Loci for Atherosclerosis Kelly Frazer Natural Antibodies and Protecting the Vasculature Joseph Witztum Gut Flora Metabolism of Dietary Phosphatidylcholine and the Pathogenesis of Cardiovascular Disease Stan Hazen Q & A
12:20 – 12:25	Closing Comments
12:25 PM	Final Adjournment