| 5:00 pm |
Registration |
| 7:00 pm |
Dinner |
| 8:00 am |
Breakfast |
SESSION 1: Transmission 1
Lisa Frenkel, Ron Swanstrom |
| 9:00 |
Opening Remarks
Ron Swanstrom |
| 9:10 |
MONOTYPIC HIV DNA SEQUENCES INCREASE IN PREVALENCE DURING SUPPRESSIVE ANTIRETROVIRAL THERAPY SUGGESTING THAT ROLIFERATION OF HIV-1-INFECTED CELLS SUSTAINS INFECTION
Lisa Frenkel |
| 9:35 |
ROLE OF DONOR GENITAL TRACT HIV-1 DIVERSITY IN THE TRANSMISSION BOTTLENECK
Peter Hraber |
| 9:50 |
GENERATING GENETICALLY TAGGED INFECTIOUS MOLECULAR CLONES FOR USE IN NONHUMAN PRIMATE TRANSMISSION AND PATHOGENESIS STUDIES
Brandon Keele |
| 10:05 |
A DEEPER VIEW OF TRANSMITTED/FOUNDER VIRUSES DURING ACUTE HIV-1 INFECTION USING 454 WHOLE GENOME DEEP SEQUENCING
Damien C. Tully |
| 10:20 |
COMPARING MODELS OF HIV AND HCV EVOLUTION IN EARLY INFECTION
Elena Giorgi |
| 10:35 |
Coffee Break |
SESSION 2: Model 1
Allen Rodrigo, Sebastian Bonhoeffer |
| 11:05 |
RECOVERING TRANSMISSION STRUCTURE AND DYNAMICS FROM VIRAL SEQUENCE DATA
Sebastian Bonhoeffer |
| 11:30 |
A MIXED EFFECTS MODEL OF EVOLUTION FOR DETECTING INDIVIDUAL SITES SUBJECT TO EPISODIC DIVERSIFYING SELECTION
Konrad Scheffler |
| 11:45 |
DETECTING SELECTIVE EFFECTS USING TREE RECONSTRUCTIONS
Richard Liang |
| 12:00 pm |
MEASURING THE STRENGTH OF SELECTION USING DEEP DIVERSITY DATA
Richard Neher |
| 12:15 |
VIRUS-GLUE: STANDARDIZED ANALYSIS OF VIRAL SEQUENCE DATA
Rob Gifford |
| 12:30 |
Lunch |
SESSION 3: Epi
Mike Worobey, Andrew Leigh Brown |
| 1:45 |
MOLECULAR EPIDEMIOLOGY OF RETROVIRUSES IN DEEP TIME (AND DEEP OCEANS)
Mike Worobey |
| 2:10 |
COMPREHENSIVE ANALYSIS OF SIVAGMVER INFECTION IN WILD AFRICAN GREEN MONKEYS FROM THE REPUBLIC OF SOUTH AFRICA: PREVALENCE, INCIDENCE, DIVERSITY, NATURAL HISTORY AND EVOLUTIONARY CONSIDERATIONS
Cristian Apetrei |
| 2:25 |
A FEW EARLY HIV-1 SUBTYPE B INTRODUCTIONS INTO CENTRAL AMERICA ACCOUNT FOR MOST CURRENT CASES
Jan Albert |
| 2:40 |
ORIGIN AND FATE OF A/H1N1 INFLUENZA IN SCOTLAND DURING 2009
Andrew J. Leigh Brown |
| 2:55 |
RECONSTRUCTION OF THE GLOBAL HIV-1 GROUP M TRANSMISSION NETWORK
Joel Wertheim |
| 3:10 |
Coffee Break |
SESSION 4: CTL
Rob De Boer |
| 3:40 |
RAPID EMERGENCE OF CTL RETARDS THE EVOLUTION OF IMMUNE ESCAPES OF
HIV
Rob De Boer |
| 4:05 |
HLA-ASSOCIATED HIV MUTATIONS ARE BIASED IN FAVOUR OF FASTER ESCAPE
AND REVERSION RATES
Helen Fryer |
| 4:20 |
KINETICS OF EPITOPE-SPECIFIC CD8 T CELL RESPONSES DURING PRIMARY HIV-
1 INFECTION
Vitaly Ganusov |
| 4:35 |
BALANCE OF CTL ESCAPE AND VIRAL FITNESS IN ACUTE AND EARLY HIV
INFECTION
Justine Brown |
| 5:00 – 6:30 |
Poster Session |
| 7:00 |
Dinner |
| 8:00 pm |
Entertainment: Lightnin’ Wells |
| 8:00 am |
Breakfast |
SESSION 5: Mutation Tales
Sara Sawyer, Mary Poss |
| 9:00 |
TWO INFECTIONS ARE BETTER THAN ONE: ALTERED POPULATION DYNAMICS AND PATHOGENESIS OF FIV IN A DUAL INFECTION WITH APATHOGENIC PLV
Mary Poss |
| 9:25 |
NEW CANDIDATE HIV COFACTORS IDENTIFIED THROUGH SIGNATURES OF POSITIVE SELECTION
Sara Sawyer |
| 9:50 |
CONCOMITANT LETHAL MUTAGENESIS OF HIV-1
Louis Mansky |
| 10:05 |
ESTIMATING THE HERITABILITY OF VIRAL DETERMINATION OF PROGRESSION RATE
Emma Hodcroft |
| 10:20 |
Coffee Break |
SESSION 6: Deep Seq
Mathew Henn, Jim Mullins |
| 10:50 |
THE SEQUENCING TECHNOLOGY WAVE AND MAKING SENSE OF THE BILLIONS OF BASES
Matt Henn |
| 11:15 |
ANALYSIS OF VIRUS POPULATIONS INFECTING HVTN502/STEP TRIAL VOLUNTEERS TO ASSESS THE MECHANISMS OF THE OBSERVED SIEVE EFFECT
Jim Mullins |
| 11:40 |
RECONSTRUCTING THE EMERGENCE OF PREDICTED CXCR4-USING HIV VARIANTS WITHIN PATIENT COMPARTMENTS FROM DEEP SEQUENCE DATA: AN EXPANDED ANALYSIS
Art Poon |
| 11:55 |
USING DEEP SEQUENCING WITH A PRIMER ID TO DETECT MINORITY DRUG
RESISTANCE MUTATIONS ON THE HIV-1 RT CODING DOMAIN
Shuntai Zhou |
| 12:10 pm |
Lunch |
SESSION 7: Antibodies
Bette Korber |
| 1:30 |
A STRUCTURE-BASED B CELL MOSAIC VACCINE DESIGN STRATEGY
Bette Korber |
| 1:55 |
HOW MANY ANTIBODIES ARE NEEDED FOR NEUTRALIZATION - NEW INSIGHTS
FROM TITRATION CURVES
Carsten Magnus |
| 2:10 pm |
HIV-1 CONTINUES TO EVOLVE IN PRESENCE OF BROADLY NEUTRALIZING
ANTIBODIES MORE THAN TEN YEARS AFTER INFECTION
Antoine Chaillon |
| 2:25 |
A COMPUTATIONAL METHOD FOR PREDICTING EPITOPES OF HIV-1 BROADLY NEUTRALIZING ANTIBODY
Mojgan Haddad |
| 2:40 |
SIEVE ANALYSIS OF HIV-1 BREAKTHROUGH INFECTIONS IN THE RV144 TRIAL
Morgane Rolland |
| 2:55 |
Coffee Break |
SESSION 8: Transmission
Susan Little, Jan Albert |
| 3:25 |
HIV MOLECULAR EPIDEMIOLOGY: ARE WE MISSING PREVENTION OPPORTUNITIES?
Susan Little |
| 3:50 |
FEATURES OF THE TRANSMITTED VIRUS IN HETEROSEXUAL TRANSMISSION
Ron Swanstrom |
| 4:15 |
DYNAMICS AND FREQUENCY OF GAG TRANSMITTED POLYMORPHISMS IN
ZAMBIA
Malinda Schaefer |
| 4:30 |
TRANSMISSION DYNAMICS OF CRF50_A1D ACROSS MOST AT RISK COMMUNITIES IN THE UK
Geraldine Foster |
| 4:45 |
AUTOMATED ANALYSIS OF A1 CLUSTER DYNAMICS IN THE UK 2007-2010
Manon Ragonnet-Cronin |
| 5:00 – 6:30 |
Poster Session |
| 7:00 |
Dinner |
| 8:00 pm |
Featured Lecture: HIV Dynamics
Stuart Ray |
| 8:00 am |
Breakfast |
SESSION 9: Model 2
Katia Koelle |
| 9:00 |
CONSTRUCTING HIV INTRAHOST PHYLOGENIES UNDER DYNAMICAL SYSTEM MODELS OF CTL ATTACK
Sivan Leviyang
|
| 9:15 |
AN AGENT-BASED MODEL TO STUDY THE RELATIONSHIP BETWEEN EPIDEMICAL AND EVOLUTIONARY DYNAMICS OF HIV
Frederik Graw |
| 9:30 |
SPATIAL DYNAMICS OF HIV-1 INFECTION IN RAKAI, UGANDA
Mary Grabowski |
| 9:45 |
A STOCHASTIC MODEL OF HIV-1 SET POINT VIRAL LOAD EVOLUTION
Joshua Herbeck |
| 10:00 |
THE ROLE OF HIV-1 VIRAL LINKAGE AND VIRAL LOAD IN TREATMENT-AS-PREVENTION STUDIES
Vlad Novitsky
|
| 10:15 |
Coffee Break |
| 10:45 |
Special Lecture: John Coffin |
SESSION 10: Drugs and Drug Resistance
John Coffin |
| 11:15 |
ANTIRETROVIRAL DYNAMICS DETERMINES HIV EVOLUTION AND PREDICTS
THERAPY OUTCOME
Daniel I. S. Rosenbloom |
| 11:30 |
EMERGENCE OF DRUG RESISTANCE IN A HIV EPIDEMIC
Roberto Saenz |
| 11:45 |
INITIAL THERAPY WITH RALTEGRAVIR SELECTIVELY REDUCES 2-LTR CIRCLES
BUT NOT TOTAL HIV DNA
Matthew Strain |
| 12:00 pm |
QUANTIFYING VIRUS DYNAMICS FROM MEASURED HIV-1 2-LTR CIRCLES FROM
PERIPHERAL BLOOD MONONUCLEAR CELLS FOLLOWING RALTEGRAVIR
INTENSIFICATION IN SUBJECTS WITH SUSTAINED VIRAL SUPPRESSION
Ryan Zurakowski |
| 12:15 |
Final Adjournment |
| 12:30 |
Lunch (optional) |
