PROGRAM

The over all scope of the program is to i) provide a detailed and intense review of currently appreciated mechanisms of pain and its processing; ii) specific review of a number of specific clinical states where in the basic understanding of pain biology will be considered in the light of the specific syndromes and iii) review of the mechanisms of analgesic drugs and the applications of these principals to the management of the clinical pain state.

Wednesday, June 20, 2012
3:00 pm - 6:30 pm Registration
5:30 pm - 6:30 pm Social Hour
Thursday, June 21, 2012
7:00 am Registration & Continental Breakfast
8:00 - 8:30 am Welcome, William Muir III, DVM, PhD, DACVA, DACVECC
8:30 - 9:00

Pain: Introductory Concepts/Taxonomy, Tony Yaksh, PhD

  • Historical concepts
  • Concepts of nociception
  • Hyperalgesia/allodynia
  • Sensory Discriminative vs Affective motivational
9:00 - 10:00

Peripheral nerve and DRG, Tony Yaksh, PhD

  • General anatomy of peripheral sensory (DRG / somatic/autonomic)
  • Specialized endings
  • Sensory axon morphology
  • DRG morphology
  • Schwann cells
  • Trophic regulation / Axon transport
  • Nerve injury response: retrog Chrom/Wallerian Degen (overview)
10:00 - 10:30 Break
10:30 - 11:30

Primary Afferents: Modality, Response Coding, Linda Sorkin, PhD

  • Fiber types / Functional correlates
  • Activation properties
  • Chemosensitivity
  • Terminal plasticity: Sensitization
  • Neurogenic inflammation
11:30 - 12:30

Primary Afferents: Chemical Anatomy, Linda Sorkin, PhD

  • Neurotransmitters
  • Colocalization
  • Mechanisms of vesicle mobilization
  • Channels/Synaptic proteins
  • Central terminal receptors / channels
12:30 - 1:30 pm Lunch
1:30 - 2:30

Dorsal Horn Anatomy and Physiology, Andrew Todd, PhD

  • Laminar organization
  • Afferent projections: homo-/hetero-segmental & laminar distribution
  • Heterosegmental and bulbospinal input
  • Functional organization (Lam I / Lam V/Lam X)
  • Nociceptive specific / Wide dynamic range neurons
  • Convergence and integration
  • Dermatomes,Myotomes, Sclerotomes
2:30 - 3:30

Dorsal Horn Chemical Anatomy, Andrew Todd, PhD

  • Excitatory Input
  • Inhibitory input
  • Integrative convergence
3:30 - 4:00 Break
4:00 - 5:00

Spinal Projection Systems, Glenn Giesler, PhD

  • Ascending anatomic projections
  • Ipsi vs Contralateral projections
  • Supraspinal linkages
5:00 - 6:00

Thalamus, Cortex, Glenn Giesler, PhD

  • Supraspinal projections
  • Specific vs non specific linkages
  • Covariates of stimulus input and supraspinal activation
6:00 pm End of Session
Friday, June 22, 2012
8:00 - 9:00 am

Post-Tissue Injury pain processing: 1, Tony Yaksh, PhD

  • Properties of tissue injury pain phenotype.
  • Wind-up /receptive field plasticity
  • Terminal origins of spont activity / facilitated response
  • Dorsal horn pharmacology of central facilitation
  • Post synaptic receptor organization and movement
  • Phosphorylation
  • Non neuronal cells
9:00 - 9:45

Post-Tissue injury pain processing: 2, Tony Yaksh, PhD

  • Nerve injury pain phenotype.
  • Biology of the spouting terminal: Ectopic activity
  • Alterations in DRG channel/receptor biology
  • Role of inhibition loss in facilitated state.
  • Central alteration: change in transporters
  • Sympathetic sprouting
9:45 - 10:15 Break
10:15 - 11:15 Post-Nerve injury pain processing: 1, Tony Yaksh, PhD
11:15 - 12:00 pm Post-Nerve injury pain processing: 2, Tony Yaksh, PhD
12:00 - 1:15 Lunch
1:15 - 2:15

Preclinical Animal Models of Pain: Rodents, Camilla Svensson, PhD

  • Surrogate measures.
  • Models for acute/tissue injury/nerve injury
  • New modes of  evaluatiing analgesic agents.
  • Use in drug evaluation
2:15 - 3:15

Preclinical Animal Models of Pain: Large Animals, Dorothy Cimino Brown, DVM, MSCE, DACVS

  • Experimental models: Dog/Sheep/Cat /horse
  • Clinical models in drug evaluation
3:15 pm End of Session
4:00 - 10:00 pm San Diego Zoo, Reception and Dinner
Saturday, June 23, 2012
8:00 - 9:00 am

Visceral Pain, G.F. Gebhart, PhD

  • Visceral afferents (vs somatic)
  • Organization of visceral innervation
  • Spinal and supraspinal projections
  • Veterinary Pain Short Course-2012 p6
9:00 - 10:00

Cancer Pain, Patrick Mantyh, PhD, JD

  • Integrative mechanisms
    Drug therapy: Dog
10:00 - 10:15 Break
10:15 - 11:15

Arthritis, Camilla Svensson, PhD

  • Integrative mechanisms
  • Drug therapy: Dog
11:15 - 12:15 pm

Laminitis, Bernd Driessen, DVM, PhD, DACVA

  • Integrative mechanisms
  • Drug therapy
12:15 - 1:30 Lunch
1:30 - 2:30

Mechanisms of Analgesic Action, Ashley Wiese, DVM, MS, DACVA    

  • Opiates
  • NSAIDS
  • Anticonvulsant
  • TCA
2:30 - 3:30

Analgesic activity: Feline/Canine, Mark Epstein, DVM, DABVP, CVPP

  • Clinical Review Acute /Chronic
3:30 - 3:45 Break
3:45 - 4:45

Analgesic activity: Equine, Bernd Driessen, DVM, PhD, DACVA

  • Clinical Review Acute /Chronic
4:45 - 5:45

Future directions in veterinary pain management, Dorothy Brown, DVM, MSCE, DACVS

  • Opiates
  • Nonopiates
  • Toxins
5:45 - 6:00 pm Concluding comments