UC San Diego School of Medicine, Continuing Medical Education
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Program

This is a preliminary agenda and is subject to change.

Wednesday, May 7, 2014

5:00 pm Registration
7:00 pm Welcome Dinner

Thursday, May 8, 2014

7:00 am  Breakfast

Vaccines, Immunity & Restriction Factors
Session Chairs: Steve Wolinsky & Morgane Rolland

8:00 am  HIV-1 EVOLUTIONARY DYNAMICS IN HLA-B*5701 SUBJECTS WITH DIFFERENT RISK OF DISEASE PROGRESSION, * Marco Salemi
8:25 am EXPLORING THE INFLUENCE OF OLIGOMANNOSE AND COMPLEX GLYCANS ON THE MOLECULAR DYNAMICS OF HIV-1 GP120 IN THE CONTEXT OF VIRAL CORECEPTOR TROPISM, *Natasha Wood
8:50 am HIV-1 INFECTIONS WITH MULTIPLE FOUNDERS ARE ASSOCIATED WITH HIGHER EARLY VIRAL LOAD SETPOINTS, *Morgane Rolland
9:15 am MODELS OF MUTATION AND SELECTION IN B CELL MATURATION DERIVED DIRECTLY FROM A HIGH-THROUGHPUT SEQUENCING STUDY, *Connor McCoy
9:40 am EFFECTS OF RETROVIRAL RESTRICTION FACTORS ON HIV-1 PERSISTENCE IN VIVO, * Satish Pillai
10:05 am Break

Therapy, Prevention & Epidemiology
Session Chairs: Doug Richman & Grace McCormack

10:30 am HIV DIVERSIFICATION RATE CORRELATES WITH EVOLUTION AND DISTRIBUTION OF DRUG RESISTANCE, *Jeffrey Joy
10:55 am MODELING THE EFFECT OF INTEGRASE INHIBITION IN HIV-1 VIRAL DYNAMICS, * Ruy Ribeiro
11:20 am ESTIMATING THE SELECTIVE ADVANTAGE OF HIV-1 MUTANTS FROM LONGITUDINAL ALLELE FREQUENCY DATA, *Miguel Lacerda
11:45 am THE POTENTIAL EFFECTS OF WIDESPREAD ANTIRETROVIRAL TREATMENT ON HIV VIRULENCE TRENDS, *Joshua Herbeck
12:10 pm Lunch

New Software for Viral Genomic Analyses
Session Chairs: Andrew Rambaut & Art Poon

1:00 pm A TREE SHAPE KERNEL METHOD TO INFER EPIDEMIOLOGICAL PARAMETERS FROM RNA VIRUS PHYLOGENIES, *Art Poon
1:25 pm SCALABLE PHYLODYNAMIC ANALYSIS FOR HIV SURVEILLANCE, *Erik Volz
1:50 pm A TRANSMISSION TREE EMBEDDED COALESCENT PROCESS: BRIDGING WITHIN AND AMONG HOST EVOLUTIONARY RATES, * Andrew Rambaut
2:15 pm IDENTIFYING NEUTRALIZING ANTIBODY EPITOPES: EXPLOITING ENVELOPE STRUCTURE AND SEQUENCE CONTEXT, *Ben Murrell
2:40 pm Break

Empirical Molecular Epidemiology 1
Session Chairs: Andrew Leigh-Brown &  Joel Wertheim

3:00 pm HIV TRANSMISSION IN THE UNITED STATES: THE ROLES OF RISK GROUP, RACE/ETHNICITY, AND GEOGRAPHY, *Alexandra Oster
3:25 pm THE HIDDEN HISTORY OF HIV-1: ESTABLISHMENT AND EARLY SPREAD OF THE AIDS PANDEMIC, *Nuno Faria
3:50 pm THE TWO PHASES OF HIV-1 GROUP O DIVERSIFICATION, *Marie Leoz
4:15 HISTORY AND ORIGIN OF THE HETEROSEXUAL HIV-1 SUBTYPE C EPIDEMIC IN SOUTHERN AFRICA, *Eduan Wilkinson
4:45 pm Poster Session
7:00 pm Dinner

Friday, May 9, 2014

7:00 am  Breakfast

Within Host Dynamics
Session Chairs: Katrina Lythgoe & Viktor Müller

8:00 am  THE SHIFTING MOSAIC OF WITHIN-HOST HIV DYNAMICS, Katrina Lythgoe
8:25 am A FRAMEWORK INCLUDING RECOMBINATION FOR ANALYZING THE DYNAMICS OF WITHIN-HOST HIV GENETIC DIVERSITY, *Ori Sargsyan
8:50 am SLOW DESTRUCTION OF LYMPHOID ARCHITECTURE AS A DRIVER OF HIV DISEASE PROGRESSION, * Viktor Müller
9: 15 am MATHEMATICAL MODELING OF HIV RESERVOIR DYNAMICS FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANT, *Alison Hill
9:40 am Break

Cutting Edge Research on Other Viruses
Session Chair: Marco Salemi

10:00 am EARLY EVOLUTIONARILY DIVERGENT SITE IN HEPATITIS C VIRUS SUBTYPE 1A E2 PREDICTS SENSITIVITY TO BROADLY NEUTRALIZING ANTIBODIES, *Ramy El-Diwany
10:25 am THE GLOBAL CIRCULATION OF NOROVIRUS GII.3 AND GII.4, *Lydia Drumright
10:50 am INVESTIGATING THE EFFECT OF PROTEIN ENERGY MALNUTRITION ON INTRA-HOST VIRAL EVOLUTION USING A MURINE MODEL OF NOROVIRUS INFECTION, *Marco Salemi
11:15 am THE DEDUCED EVOLUTION HISTORY OF OMSK HEMORRHAGIC FEVER VIRUS,  *Alessandra Lo Presti
11:45 pm Lunch

Molecular Epidemiology Methods
Session Chairs: Thomas Leitner & Simon Frost

1:00 pm TRANSMISSION NETWORKS FROM HIV SEQUENCE DATA, * Manon Ragonnet-Cronin
1:25 pm AN ADAPTIVE BRANCH SITE RANDOM EFFECTS MODEL FOR EFFICIENT DETECTION OF EPISODIC DIVERSIFYING SELECTION, *Martin Smith
1:50 pm DETECTING ASYMMETRY IN TIME-STAMPED PHYLOGENIES, *Bethany Dearlove
2:15 pm ESTIMATING TIME OF TRANSMISSION FROM TIME-SCALED PHYLOGENIES, * Ethan Romero-Severson
2:50 pm Break

Empirical Molecular Epidemiology 2
Session Chairs: Angela McLean & Jan Albert

3:10 pm HIV VIRULENCE HAS NOT INCREASED IN THE UK SUBTYPE B EPIDEMIC, *Emma Hodcroft
3:35 pm NEW INSIGHTS INTO HIV PATHOGENESIS REVEALED BY AN EVOLUTIONARY PERSPECTIVE ON VIRULENCE, *Christophe Fraser
4:00 pm CORRELATES OF AN HIV TRANSMISSION NETWORK STRUCTURE IN THE SAN DIEGO-TIJUANA BORDER REGION, *Sanjay Mehta
4:25 pm CHARACTERISTICS OF HIV-1 TRANSMISSION FROM THOSE IN CARE IN THE ONGOING, CONCENTRATED HIV EPIDEMIC AMONG MSM IN THE NETHERLANDS, *Oliver Ratman
4:40 pm LONG-ESTABLISHED HIV-1 SUBTYPE B TRANSMISSION NETWORKS PERSIST THROUGH TRANSMISSION TO NEXT GENERATIONS OF MSM IN THE NETHERLANDS, *Daniela Bezemer
4:50 pm HIV-1 RNA LOAD IN ART-NAÏVE INDIVIDUALS IS HIGHER WITHIN HIV-1C LINEAGES (CLUSTERS) CIRCULATING IN MOCHUDI, BOTSWANA  & DYNAMICS OF THE EFFECTIVE REPRODUCTIVE NUMBER, RT, IN CIRCULATING HIV-1C LINEAGES (CLUSTERS) IN MOCHUDI, BOTSWANA*Vlad Novitsky
5:15 pm Poster Session
7:00 pm Dinner

Saturday, May 10, 2014

7:30 am  Breakfast

Latency, Reservoirs & Cure
Session Chairs: John Coffin & Brandon Keele

8:30 am USING THE “FILIBUSTER CORRECTION” METHOD TO GENERATE SUPERMAJORITY SEQUENCES REDUCES ERROR AND ARTIFACT RECOMBINATION IN ILLUMINA SEQUENCING,  *Wei  Shao
8:55 am PRIMER ID DEEP SEQUENCING OF HIV-1 V1-V3 ENV REGION TO REVEAL GENETIC STRUCTURE OF THE VIRAL POPULATION, *Shuntai Zhou
9:20 am SPATIOTEMPORAL DYNAMICS OF SIV INFECTION IN THE BRAIN OF CD8-DEPLETED AND NATURALLY PROGRESSING RHESUS MACAQUES, *Brittany Rife
9:45 am DISSECTING THE TEMPORAL DYNAMICS OF HIV-1 WITHIN INTESTINAL MUCOSAL TISSUE , *Damien Tully
10:10 am Break
10:30 am THE ROLE OF HIV INTEGRATION SITES IN EXTENSIVE CLONAL EXPANSION OF INFECTED CELLS IN PATIENTS, *John Coffin
10:55 am GENERATION OF AN ULTRA-DEEP BARCODED SIV TO IDENTIFY AND QUANTIFY VIRAL RESERVOIRS, *Brandon Keele
11:20 am REDUCED EVOLUTIONARY RATES REVEAL LATENCY IN THE MAJORITY OF HIV-1 LINEAGES, *Thomas Leitner
11:35 am A DYNAMIC PATHOGEN-HOST MODEL WITH SEQUENCE EVOLUTION REVEALS THE EFFECT OF LATENCY ON HIV-1 DIVERGENCE AND DIVERSITY, *Taina Immonen
11:50 am Final Adjournment

Satellite Symposium

Satellite Workshop on HIV Phylodynamics
Saturday, May 10, 2014
2:00 pm- 5:00 pm                            
Loews Ventana Canyon Hotel

NOTE: Room reservation fees and arrangements will not be included for the satellite workshop. You will need to make reservations for the extra night on your own.

Sponsored by the PANGEA-HIV Consortium in conjunction with the 21st International Workshop on HIV Dynamics and Evolution

PANGEA-HIV (Phylogenies And Networks for Generalized Epidemics in Africa) is a major new initiative funded by the Bill and Melinda Gates Foundation primarily to generate a large volume of sequence data from African HIV cohorts to facilitate the phylodynamic characterization of generalized HIV epidemics.

Sequence data generated under PANGEA-HIV will be publicly available, and the consortium dataset, including matched demographic data, will be available for collaborative research from external groups. In this first PANGEA-HIV Workshop invited experts in the field will present their latest work and members of the consortium will outline the partner sites, the plans for data generation and mechanism of access for external collaborators.

Consortium Executive Group: Deenan Pillay, UCL/Africa Centre (PI); Christophe Fraser (Imperial College); Paul Kellam (Wellcome Trust Sanger Institute); Andrew Leigh Brown (University of Edinburgh); Tulio d’Oliveira (Africa Centre)

All participants at the 21st International HIV Dynamics & Evolution are invited to attend, FREE of charge but you must register before the start of the main meeting.

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Content is subject to change without notice. Please refer to the activity website for the most current information.
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