UC San Diego School of Medicine, Continuing Medical Education
(858) 534-3940 | ocme@ucsd.edu | cme.ucsd.edu



Agenda

Agenda as of 3/25/16

Sunday, April 24, 2016
4:30 pm Registration
6:00 pm Dinner
Monday, April 25, 2016
7:30 am Breakfast
Genetic & Genomic Methodology
Session Chairs: Christophe Fraser, Manon Ragonnet
8:00 am USING DSPS_HIV, A HIGHLY-CUSTOMISABLE AGENT-BASED HIV EPIDEMIC SIMULATOR, TO INVESTIGATE ‘MISSING MEN’ IN WESTERN HETEROSEXUAL HIV EPIDEMICS, Emma Hodcroft
8:20 am DATING EARLY HIV INFECTIONS: DATA, CHALLENGES, AND MODELS, Ha Youn Lee
8:40 am A PHYLODYNAMICS PIPELINE FOR PATHOGEN SEQUENCE DATA, Mukarram Hossain
9:00 am DETECTING SELECTION IN SEXUAL HIV-1 TRANSMISSION EVENTS, David Siefert
9:20 am TEMPORAL DYNAMICS OF SET-POINT VIRAL LOAD OF HIV IN RAKAI DISTRICT, UGANDA, FOLLOWS PREDICTIONS FROM TRANSMISSION-VIRULENCE EVOLUTIONARY MODEL, Francois Blanquart
9:40 am Discussion
10:00 am Coffee Break
Latency and Reservoirs I
Session Chairs: Helen Fryer, Alan Perelson
10:30 am ESTABLISHMENT AND MAINTENANCE OF HIV-1 DNA RESERVOIRS, Jan Albert
10:50 am AN EVOLUTIONARY ROLE FOR HIV LATENCY IN ENHANCING VIRAL TRANSMISSION, Igor Rouzine
11:10 am HIV PROVIRUSES IN CLONALLY EXPANDED CELLS ARE STUCTURALLY DIVERSE, Frank Maldarelli
11:30 am HIV INTEGRATION SITES IN SURVIVING RESERVOIR CELLS ARE ENRICHED IN GENES ASSOCIATED WITH T-REGULATORY CELL FUNCTION, James Mullins
11:50 am HIV PERSISTENCE DURING ART APPEARS TO FAVOR PROVIRUSES INTEGRATED IN GENES INVOLVED IN EARLY EVENTS OF T CELL ACTIVATION AND IN GENES INVOLVED IN T CELL HOMEOSTASIS AND EFFECTOR DIFFERENTIATION, Milika Aid
12:10 pm Discussion
12:30 pm Lunch
Latency Reservoirs II
Session Chairs: James Mullins, Jan Albert
1:30 pm

AN HIV RESERVOIR EXISTS IN TISSUES THAT APPEARS UNTOUCHED BY ART, Michael McGrath

1:50 pm A SMALL FRACTION OF PROVIRUSES IN CLONAL CELL POPULATIONS EXPRESS UNSPLICED HIV RNA IN VIVO, Andrew Musick
2:10 pm DISSECTION OF LATENT HIV RESERVOIRS FOLLOWING CULTIVATION EX VIVO, Breana Hall
2:30 pm DETERMINANTS OF THE EFFICACY OF HIV LATENCY REVERSING AGENTS AND IMPLICATIONS FOR DRUG AND TREATMENT DESIGN, Ruian Ke
2:50 pm SWITCHING FROM A HIGH TO A LOW VIRAL LOAD STEADY STATE IN SIV INFECTED MACAQUES BY REVERSING CD8 T CELL EXHAUSTION WITH TRANSIENT ANTI-PD-L1 INFUSIONS, Alan Perelson
3:10 pm Discussion
3:30 pm Refreshment Break
Epidemiology I
Session Chairs: Simon Frost, Narendra Dixit
4:00 pm PHYLOGENETIC ESTIMATION OF CONTACT NETWORK PARAMETERS WITH KERNEL-ABC, Rosemary McCloskey
4:20 pm THE PROBABILITY OF AN OBSERVED PHYLOGENETIC TOPOLOGY FROM TWO OR MORE INFECTED PERSONS DEPENDS ON THEIR EPIDEMIOLOGICAL LINKAGE, Thomas Leitner
4:40 pm IDENTIFYING TRANSMISSION CLUSTERS FROM HIV PHYLOGENIES, Bethany Dearlove
5:00 pm INFERENCE OF EPIDEMIC CONTACT NETWORKS FROM HIV PHYLOGENETIC TREES, Federica Giardina
5:20 pm Discussion
5:40 pm Adjourn
6:00 pm Dinner
7:30 pm Main Poster Session
Tuesday, April 26, 2016
7:30 am Breakfast
Epidemiology II
Session Chairs: Bethany Dearlove, Thomas Leitner
8:00 am REDUCING THE NOISE IN STUDIES OF THE HUMAN FACTORS OF VIRULENCE BY PHYLOGENETIC INFERENCE OF INDIVIDUAL IMMUNE SYSTEM CONTRIBUTION, Tanja Stadler
8:20 am DYNAMICS OF HIV-1 SPREAD IN GERMANY INFERRED FROM RECENTLY TRANSMITTED VIRUSES, Kaveh Yousef
8:40 am CHARACTERISING HIV TRANSMISSION RISK FACTORS IN MEN WHO HAVE SEX WITH MEN USING GENETIC SOURCE ATTRIBUTION AND PHYLOGENETIC CLUSTERING, Stephane Le Vu
9:00 am CLUSTERING OF HIV-1 SEQUENCES AMONGST MEN WHO HAVE SEX WITH MEN IN BEIJING, CHINA, Simon Frost
9:20 am INFERENCE AND CHARACTERIZATION OF A TRANSMISSION NETWORK IN AN OPIOID DRIVEN HIV 1 OUTBREAK, Ells Campbell
9:40 am Discussion
10:00 am Coffee Break
Drug Resistance
Session Chairs: Morgane Rolland, Mary Kearney
10:30 am EVALUATING THE SUITABILITY OF VARIOUS NEXT-GENERATION SEQUENCING PLATFORMS FOR THE ESTABLISHMENT OF HIGH-THROUGHPUT, HIGHLY SENSITIVE HIV DRUG RESISTANCE GENOTYPING IN RESOURCE-LIMITED SETTINGS WITH A HIGH BURDEN OF HIV, Simon Travers
10:50 am EVOLUTION OF DRUG RESISTANCE MUTATIONS AND VIRAL LOAD AMOUN HIV PATIENTS ON FAILING FIRST LINE ART, J. Wu
11:10 am INCREASES IN PROTEIN STABILITY ENABLE THE EVOLUTION OF DRUG RESISTANCE IN HIV‑1, Abayomi Olabode
11:30 am SOLVING THE MYSTERY OF THE MISSING MEN IN THE UK HIV DRUG RESISTANCE DATABASE: A NETWORK-BASED APPROACH, Manon Ragonnet
11:50 am REALISTIC NGS HIV DRUG RESISTANCE DATA SIMULATION AND ITS APPLICATION TO THE EVALUATION OF MUTATION-CALLING SOFTWARE, Imogen Wright
12:10 pm Discussion
12:30 pm Lunch
Immunology & Vaccines
Session Chairs: Simon Travers, Milika Aid
1:30 pm BASELINE (PRE-VACCINATION) GENE EXPRESSION SIGNATURE THAT PREDICTS PROTECTION FROM ACQUISITION OF SIV INFECTION IN CHALLENGED RHESUS MACAQUES MODEL, Milika Aid
1:50 pm MATURATION PATHWAY FROM GERMLINE TO BROAD HIV-1 NEUTRALIZER OF A CD4-MIMIC ANTIBODY, Peter Hraber
2:10 pm THE BROADEST BNABS TARGET MORE CONSERVED HIV-1 ENV EPITOPES, Morgane Rolland
2:30 pm DYNAMICS OF HIV-1 FOLLOWING INFUSION OF VRC01 IN INFECTED INDIVIDUALS, Erwing Cardozo Ojeda
2:50 pm Discussion
3:30 pm Cranberry Bog Tour/Free Time (Bus leaves from Swope Conference Center)
7:00 pm Lobster Boil Dinner
Wednesday, April 27, 2016
7:30 am Breakfast
Within Host Dynamics I
Session Chairs: Sivan Leviyang, Andrew Leigh Brown
8:00 am ON THE DEATH RATE OF ABORTIVELY INFECTED CELLS: ESTIMATION FROM SHIV INFECTION, Ruian Ke
8:20 am USING CROSS-PATIENT PHYLOGENIES OF HIV-1 DEEP SEQUENCES TO QUANTIFY WITHIN-HOST DIVERSITY AND ROBUSTLY IDENTIFY MULTIPLE INFECTIONS, RECOMBINATION, CONTAMINATION AND TRANSMISSION EVENTS, Chris Wymant
8:40 am INTRAHOST EVOLUTION OF THE HIV-1 POLYPROTEIN GAG, Elizabeth Johnson
9:00 am GENERALIZED COALESCENTS ARE NECESSARY FOR MODELING INTRAHOST HIV EVOLUTION, T. Wallstrom
9:20 am LOW IN VIVO FITNESS OF HIV-1 SUBTYPE C UNDERLIES TREATMENT SUCCESS DESPITE HIGH BASELINE VIRAL LOADS, Narendra Dixit
9:40 am Discussion
10:00 am Coffee Break
Within Host Dynamics II
Session Chairs: Elizabeth Johnson, Marcia Kalish
10:30 am INCREASED LYMPHOCYTE TRAFFICKING AS A NOVEL APPROACH TO HIV-1 CLEARANCE, Helen Fryer
10:50 am STUDYING HIV 1 TRANSMITTED VARIANTS IN THE FEMALE GENITAL TRACT USING UNBIASED NEXT GENERATION SEQUENCING, A. Piantadosi
11:10 am THE FORM AND RATE OF CTL ESCAPE DRIVEN BY MULTI-EPITOPE CTL RESPONSE IN ACUTE HIV-1 INFECTION, Sivan Leviyang
11:30 am TRACING INTRA PATIENT HIV 1 EVOLUTIONARY DYNAMICS FOR IMPROVING THE IDENTIFICATION OF RECENT INFECTIONS, J. Wu
11:50 am Discussion
12:15 pm Lunch & Final Departure (unless staying for PANGEA Satellite)

*For those coming early or staying over, we recommend taking the Ferry to Martha's Vineyard.

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UC San Diego School of Medicine, Continuing Medical Education•9500 Gilman Drive, MC0947•La Jolla, CA 92093-0947
Phone: (858) 534-3940• Toll-Free: (888) 229-6263• Fax: (858) 534-1896•E-mail: ocme@ucsd.edu•Website: cme.ucsd.edu

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