UC San Diego School of Medicine, Continuing Medical Education
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Program

This is a preliminary agenda and subject to change.

Wednesday, May 13, 2015
Location: art’otel

5:00 pm Registration
7:00 pm Welcome Reception/Dinner

Thursday, May 14, 2015
Location: Hungarian Academy of Sciences

ORIGIN AND GLOBAL EVOLUTION OF THE EPIDEMICS
Session Chairs: Michael Worobey and Ahidjo Ayouba

9:00 am Welcome and Introductions
9:15 am

ADAPTATIONS FACILITATING CROSS-SPECIES TRANSMISSION AND EMERGENCE OF SIVSM IN RHESUS MACAQUES, *Alison Hill

9:35 am CORRELATION BETWEEN HISTORICAL LACK OF MALE CIRCUMCISION AND THE EPIDEMIC OF HIV-2, *Joao Sousa
9:55 am PHYLOGENETICS AND PHYLOGEOGRAPHY OF HIV-1 SUBTYPE G ENV REVEAL COMPLEX EVOLUTIONARY PATTERNS AROUND THE EPICENTRE OF THE HIV-1 EPIDEMIC, *Jeffrey R. Dorfman
10:15 am ORIGIN OF HIV-1 GROUP O AND P IN WESTERN LOWLAND GORILLAS, *Mirela D'arc
10:30 am Break

WITHIN-HOST DIVERSITY AND EVOLUTION #1
Session Chairs: Ron Swanstrom and Richard Neher

11:00 am USING DEEP SEQUENCING TO REVEAL COMPARTMENTALIZATION OF HIV-1 POPULATIONS WITHIN THE BODY, *Ronald Swanstrom
11:20 am SEQUENCE SPACE EXPLORATION AND POPULATION DYNAMICS OF HIV-1 QUASISPECIES, *Richard Neher
11:40 am PARALLEL EVOLUTION OF HIV-1 IN A LONG TERM EXPERIMENT, *Frederic Bertels
12:00 pm PHYLOGENETIC RECONSTRUCTION OF VIRAL QUASISPECIES DYNAMICS, *Veronika Boskova
12:15 pm RECOMBINATION FACILITATES SURVIVAL OF LATENT HIV-1 LINEAGES IN PRODUCTIVELY INFECTED CELLS, *Taina Immonen
12:30 pm Lunch

WITHIN-HOST DIVERSITY AND EVOLUTION #2
Session Chairs: Jan Albert and Grace McCormack

2:00 pm WHOLE-GENOME DEEP SEQUENCING OF LONGITUDINAL SAMPLES FROM HIV-1 PATIENTS FOLLOWED FROM EARLY INTO CHRONIC INFECTION, *Jan Albert
2:20 pm TOWARDS EMPIRICALLY-DERIVED SEQUENCE SPACE AND FITNESS LANDSCAPES OCCUPIED BY RNA VIRUSES, *Marco Vignuzzi
2:40 pm EXTREME HETEROGENEITY IN GENETIC DIVERSITY AND MOLECULAR EVOLUTION FOUND IN CHRONIC HCV INFECTION, *Jayna Raghwani
3:00 pm PACBIO SINGLE MOLECULE REAL TIME SEQUENCING OF THE HCV ENVELOPE DIVERSITY FROM EARLY ACUTE INFECTION TO CHRONICITY, *Cynthia Ho
3:15 pm DYNAMICS OF CTL ESCAPE DURING EARLY ACUTE HIV-1 INFECTION REVEALED BY DENSE TEMPORAL SAMPLING AND TARGETED DEEP SEQUENCING, *Sivan Leviyang
3:30 pm Break

IMMUNE ESCAPE AND VACCINE RESEARCH
Session Chairs: James Mullins and Morgane Rolland

3:50 pm NO EVIDENCE OF STRONGER NEUTRALIZING ANTIBODY RESPONSES IN RV144 BREAKTHROUGH VACCINE RECIPIENTS TWO TO THREE YEARS AFTER HIV INFECTION, *Morgane Rolland
4:10 pm ASSESSING THE PROPENSITY OF HIV-1 TO EVOLVE ANTIBODY ESCAPE VARIANTS DURING FREE VIRUS AND CELL-CELL TRANSMISSION, *Carsten Magnus
4:25 pm THE ROLE OF TRANSMITTED AND DE NOVO CELLULAR IMMUNE ESCAPE IN HIV DISEASE PROGRESSION, *Jonathan Carlson
4:45 pm INFLUENCE OF RECOMBINATION ON ACQUISITION AND REVERSION OF IMMUNE ESCAPE AND COMPENSATORY MUTATIONS IN HIV-1, *Helen Alexander
5:00 pm THE CONSERVED ELEMENTS (CE) APPROACH TO HIV VACCINE DESIGN, *James Mullins
5:20 pm Posters
7:00 pm Dinner at Hungarian Academy of Sciences

Friday, May 15, 2015
Location: Hungarian Academy of Sciences

LATENCY, RESERVOIRS AND CURE
Session Chairs: Alan Perelson and Mary Kearney

9:00 am CARD-SGS REVEALS PERSISTENT EXPRESSION OF HIV-1 RNA IN CLONALLY EXPANDED HIV-INFECTED CELLS DURING ART, *Mary Kearney
9:20 am PERSISTENT AND PROLIFERATING HIV-INFECTED CELLS: TISSUE-DISTRIBUTION AND EXPRESSION OF VIRAL RNA AND PROTEIN, *James Mullins
9:40 am MODELING THE EFFECTS OF VORINOSTAT IN VIVO REVEALS BOTH TRANSIENT AND DELAYED ACTIVATION OF HIV TRANSCRIPTION IN LATENTLY INFECTED CELLS, *Alan Perelson
10:00 am TARGETING CCR5 RECEPTOR USING GENE THERAPY WILL NOT BE SUFFICIENT TO CURE HIV, *Aridaman Pandit
10:15 am EFFECT OF THE LATENT RESERVOIR ON THE EVOLUTION OF HIV AT THE WITHIN- AND BETWEEN-HOST LEVELS, *Hilje Doekes
10:30 am Break

WITHIN-HOST DYNAMICS
Session Chairs: Rob De Boer and Sebastian Bonhoeffer

11:00 am HOW RAPIDLY ARE HIV-1 INFECTED CELLS KILLED? *Rob De Boer
11:20 am HIV CONTROL AFTER TREATMENT CESSATION: MATHEMATICAL MODEL PREDICTION, *Jessica Conway
11:40 am MODELLING ONGOING REPLICATION OF HIV IN DRUG SANCTUARIES, *Helen Fryer
12:00 pm A ROBUST SCALING LAW ESTIMATES THE REQUIRED DURATION OF TREATMENT WITH HIV-1 MUTAGENS, *Vipul Gupta
12:15 pm TARGETING HIV LATENCY, *Feng Fu
12:30 pm Lunch

PHYLOGENETIC INSIGHTS INTO EPIDEMIC DYNAMICS
Chairs: Tanja Stadler and Tulio Oliveira

2:00 pm DETECTION OF TRANSMISSION CLUSTERS IN HIV PHYLOGENIES, *Tanja Stadler
2:20 pm PHYLOGEOGRAPHIC METHODS GIVE INSIGHT INTO THE EPIDEMIOLOGICAL DYNAMICS BETWEEN HIV-1 RISK GROUPS, *Denise Kühnert
2:35 pm BAYESIAN INFERENCE OF TRANSMISSION PATTERNS FROM TIMED PHYLOGENIES, *Caroline Colijn
2:50 pm NEAR FULL LENGTH HIV-1 SEQUENCING TO UNDERSTAND HIV PHYLODYNAMICS IN AFRICA IN REAL TIME, *Tulio de Oliveira
3:10 pm USING PHYLOGENETIC TOOLS TO ESTIMATE ASPECTS OF HIV TRANSMISSION DYNAMICS IN GENERALIZED HIV EPIDEMICS: FINDINGS FROM THE PANGEA-HIV METHODS COMPARISON EXERCISE, Oliver Ratmann
3:30 pm Break

THERAPY, PREVENTION, AND EPIDEMIOLOGY
Session Chairs: Annemie Vandamme and Oliver Laeyendecker

4:00 pm HIV-1 TRANSMITTED DRUG RESISTANCE: NEW INSIGHTS INTO THE TRANSMISSIBILITY OF SDRMS, *Ana Abecasis
4:15 pm THE IMPORTANCE OF PROTEIN STABILITY FOR THE EVOLUTION OF HIV DRUG RESISTANCE, *Abayomi Olabode
4:30 pm DIRECT COMPARISON OF SEROLOGIC ASSAYS AND VIRAL DIVERSITY MEASURES FOR IDENTIFYING INDIVIDUALS WITH RECENT HIV INFECTION, *Oliver Laeyendecker
4:50 pm NGS COMBINED WITH PHYLOGENETIC ANALYSIS TO DETECT SUPER-INFECTION IN HIV-1 INFECTED INTRAVENOUS DRUG USERS, *Simona Paraschiv
5:10 pm RECONCILING NAMED PARTNER AND GENETIC PARTNER HIV-1 TRANSMISSION NETWORKS IN NEW YORK CITY, *Joel Wertheim
5:30 pm Posters
7:00 - 10:00 pm Dinner Cruise (Advanced sign-up required)

Saturday, May 16, 2015
Location: Hungarian Academy of Sciences

HIV VIRULENCE AND CONTROL
Session Chairs: Andrew Leigh Brown and Jonathan Carlson

9:00 am ESTIMATING THE RESPECTIVE CONTRIBUTIONS OF HUMAN AND VIRAL GENETIC VARIATION TO HIV CONTROL, *István Bartha
9:20 am ESTIMATING THE BETWEEN-HOST HERITABILITY OF VIRAL TRAITS: OLD-SCHOOL PARENT-OFFSPRING VERSUS MODERN PHYLOGENETICS, *Gabriel Leventhal
9:40 am DETERMINING THE VIRAL GENETIC BASIS OF HIV VIRULENCE USING WHOLE GENOME SEQUENCING, *Chris Wymant
10:00 am IMPORTANCE OF TRAIT SELECTION IN ESTIMATING VIRAL CONTRIBUTION TO VIRULENCE IN HIV INFECTION, *Venelin Mitov
10:15 am MODELING HIV VIRULENCE EVOLUTION IN THE CONTEXT OF IMMUNE ESCAPE, *C. H. van Dorp
10:30 am Break

BIOINFORMATICS SOFTWARE AND ALGORITHMS FOR HIV/VIRAL RESEARCH
Session Chairs: Sergei Kosakovsky Pond and Erik Volz

11:00 am FULL-LENGTH ENVELOPE ANALYSIS (FLEA): A PIPELINE AND WEB SERVICE FOR FULL-LENGTH ENV SEQUENCE ALIGNMENT, ANALYSIS, AND VISUALIZATION, *Kemal Eren
11:15 am SELECTION OF ANTIGEN SWARMS FROM NEUTRALIZING ANTIBODY DEVELOPMENT AGAINST HIV-1, *Peter Hraber
11:30 am CLUSTER RECONSTRUCTION IN SIMULATED TRANSMISSION CHAINS, *Manon Ragonnet-Cronin
11:45 am PHYLODYNAMIC INFERENCE OF CONTACT NETWORK STRUCTURE, *David Rasmussen
12:00 am QUANTITATIVE METHOD FOR THE DELINEATION OF HIV-1 SPECIFIC ANTIBODY EPITOPE REACTIVITY IN POLYCLONAL PATIENT SERA, *Nathanael Hoze
12:15 pm Final Adjournment

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